In this video we will discuss the mechanism of muscle contraction, which is initiated by tropomyosin moving and exposing the binding sites for myosin on the actin filament. This further allows a cross-bridge to be formed in between the myosin and actin filaments.Calcium binds to troponin and tropomyosin slides from the actin filaments’ binding site allowing the heads of myosin to bind to the actin’s active sites hence forming a cross-bridge.
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Reference & Resources:
Squire, J. M. (2016). Muscle contraction: Sliding filament history, sarcomere dynamics, and the two Huxleys. Global cardiology science & practice, 2016(2).
Watanabe, S., Fukuhara, S., Fujinaga, T., & Oka, H. (2017). Estimating the minimum stimulation frequency necessary to evoke tetanic progression based on muscle twitch parameters. Physiological Measurement, 38(3), 466.
SANDOW, A. (1965). Excitation-contraction coupling in skeletal muscle. Pharmacological reviews, 17(3), 265-320.
Ebashi, S., & Endo, M. (1968). Calcium and muscle contraction. Progress in biophysics and molecular biology, 18, 123-183.
(Ebashi & Endo, 1968)
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